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Cisapride is a parasympathomimetic which acts as a serotonin 5-HT₄ agonist. Stimulation of the 5-hydroxytryptamine receptors increases acetylcholine release in the enteric nervous system. These are sold under a trade list Prepulsid (Janssen-Ortho) & Propulsid (in the U.S.).

Clinical uses
Cisapride increases muscle tone in the esophageal sphincter in people with gastroesophageal reflux disease. It besides increases stomachic voidance inside humans by having diabetic gastroparesis. It has been utilized to address intestine constipation.

Within several countries it has been either withdrawn or even has got its indications limited due to reports all about long QT syndrome due to cisapride, which predisposes to arrhythmias.

Sources
Brenner, G. M. (2000). Materia medica. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6 Canadian Pill pusher Association (2000). Compendium of Pharmaceutic & Specialties (Twenty-fifth ed.). Toronto, In: Webcom. ISBN 0-919115-76-4

Cisapride (Propulsid)
Information from the RxList.

Propulsid Warning
Notification of important changes in the U.S. FDA Propulsid labeling to reflect new safety information, including recommendations for performing diagnostics tests prior to any use.

Use of Cisapride in Children
A Medical Position Statement of the North American Society for Pediatric Gastroenterology and Nutrition. Discusses the risks and benefits of this medication for treating gastroesophageal reflux and other conditions.

Cisapride and Arrhythmias
New Zealand government safety bulletin.

DrugDigest: Cisapride ( Propulsid )
Information on dosage, usage, side effects, interactions, and drug comparisons.

Medicines Control Agency announces withdrawal of Cisapride
Letter withdrawing Cisapride (Prepulsid) from the UK.